Application | imidazo [1,2-A] Pyrazine compounds are nitrogen-containing heterocyclic compounds of traditional Chinese medicine strong biological activity of a synthetic block, heterocyclic compounds is a kind of strong biological activity of small molecule compounds, widely used in biological medicine, pesticides, optoelectronic materials and other fields, especially the 6-halogenated imidazo [1,2-A] pyrazine active small molecule compounds is the major pharmaceutical companies research hotspot. |
preparation | 6-bromoimidazo [1, there are few reports on the synthesis of 2-A] pyrazine-8-amine. In this paper, 6, 8-dibromoimidazo [1,2-a] pyrazine as the starting material, 6-bromoimidazo [1,2-A] pyrazine-8-amine [1] was obtained by aminolysis reaction. The synthesis reaction formula is as follows: |